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An article to read NMN-Part Two

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An article to read NMN-Part Two

2024-08-19 13:54:49
How to increase NAD+ content in the human body?
With the deepening of research, nicotinamide mononucleotide (NMN), the precursor of NAD+, was discovered, which is currently the ideal NAD+ supplement.
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Scientific experiments have found that after taking NMN orally, it will enter the blood within 2-3 minutes, increase the NMN content in the body within 15 minutes, and increase the NAD+ content in the body within 30 minutes, thereby achieving various effects of delaying aging.

In 2013, experiments at Harvard University's Paul Glenn Center on Aging confirmed that NMN can extend the life span of mammals by more than 30%.

In 2016, a research team led by Shinichiro Imai, a professor at the University of Washington in the United States, published their research results in the American scientific journal Cell Metabolism: the anti-aging effect of NMN was confirmed, and they began to try human applications.

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In 2018, Harvard Medical School professor David Sinclair published experimental results in the authoritative academic journal "Cell", which once again proved the anti-aging function of NMN.

Well-known scientific research institutions such as Harvard University in the United States, University of Washington, and Keio University in Japan have conducted multiple studies on NMN, and relevant results have been published in authoritative academic publications such as Cell, Nature, and Science. NASA has also joined the research on NMN. They believe that NMN can repair DNA damage and protect astronauts from cosmic rays.

Why choose NMN?
There are so many NAD+ precursors, why choose NMN?
From the perspective of supplementing NAD+, the precursors that can supplement the three metabolic cycles of NAD+ are: niacin, tryptophan, nicotinamide, nicotinamide ribose (NR) and NMN.

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The conversion of tryptophan to NAD+ requires 8 steps;
The conversion of nicotinamide to NAD+ requires 3 steps;
The conversion of nicotinamide ribose (NR) to NAD+ requires 2 steps;
Conversion of NMN to NAD+ requires only 1 step.
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Because NAD+ is unstable in the environment and has a large molecular weight that cannot be directly absorbed, external supplementation is not feasible.

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