The role of fisetin

Osteoarthritis is a common inflammatory disease in the world, which is mainly characterized by pathological changes such as cartilage damage and degeneration, sclerosis of the subchondral bone and contracture and deformation of the joint capsule. The occurrence of osteoarthritis is closely related to the inflammatory environment in the joints, oxygen gradient disorders, accumulation of senescent cells, etc. In response to the above factors, laccasein can prevent the development of osteoarthritis through different pathways.Fisetin can promote the apoptosis of senescent cells, inhibit vascularization, block the abnormal crosstalk between subchondral bone and cartilage, regulate inflammatory factors, protect chondrocytes from oxidative stress and promote the apoptosis of senescent cells.